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Blog Category:

Breast Cancer

2/17/2010
Ryan Newhouse
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Breast Cancer Drug Approved for Extended Use, says FDA

The FDA has approved the use of Tykerb (lapatinib) in combination with Femara (letrozole) for postmenopausal women with breast cancer. For free information about breast cancer, contact the breast cancer medical malpractice attorneys of Pittsburgh, Pennsylvania.

2/2/2010
Ryan Newhouse
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Lymphedema after Breast Cancer Reduced by Physiotherapy

A report has found that a unique massage technique, physiotherapy, can stop lymphedema from developing in some women when performed after breast cancer surgery that involves dissection of certain lymph nodes. For more free information about breast cancer, contact the breast cancer attorneys of Pittsburgh, Pennsylvania.

1/26/2010
Joshua L. Berger
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Avastin Improves Survival of Breast Cancer Patients, says UPMC Study

Breast cancer is a deadly disease. But if if it diagnosed early, you can be cured. The failure to diagnose breast cancer may be medical malpractice. This blog discusses the treatment of women with breast cancer that has spread. A study shows that Avastin can improve survival for these women.

1/26/2010
Joshua L. Berger
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Annual Mammograms at Age 40 is the Standard, says Top Radiology Group

Mammograms can find your breast cancer, but only if they are done and interpreted accurately. The failure to order mammograms or to miss cancer on a mammogram may be medical malpractice. The American College of Radiology recommends annual mammograms beginning at age 40 for average risk women, and those with high risk of breast cancer should have mammograms and MRI beginning at age 30.

11/17/2009
Lisa Wisilosky
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New Recommendations for Mammography Screenings

If your breast cancer was missed, or not timely and properly diagnosed or treated, you have come to the right place. Our attorneys specialize in breast cancer cases.

9/4/2009
Lisa Wisilosky
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Study Finds Women Can Reduce Their Risk of Breast Cancer

According to a report by the American Institute for Cancer Research, women can cut their risk of breast cancer by at least 40% if they take some preventative steps.  The researchers looked at links between breast cancer and diet, body weight and physical activity.

The recent study is an update from a 2007 review of more than 800 studies.  However, the newly updated review includes evidence from an additional 81 studies that have been published since then. 

The report on breast cancer is part of the Continuous Update Project.  The long-term goal is to continuously update the findings of the expert report so that cancer prevention advice is always based on the latest research.

For free information about breast cancer, contact the medical malpractice attorneys of Pennsylvania at Berger & Lagnese.



7/1/2009
Lisa Wisilosky
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Study Shows Link Between Metabolic Syndrome and Breast Cancer

According to a recent study which was published in a journal for the American Association for Cancer Research, metabolic syndrome may play a role in the risk of postmenopausal breast cancer.

Metabolic syndrome, or insulin resistance syndrome, is characterized by abdominal obesity, high blood glucose levels, impaired glucose tolerance, dyslipidemia, and hypertension.  It can also increase the risk for diabetes and coronary heart disease.

In this study, the researchers used existing data from the Women's Health Initiative.  Participants included postmenopausal women aged 50 to 79 years at enrollment who had repeated measurements of components of metabolic syndrome over an eight-year period.  The results of the study suggest an association between having the metabolic syndrome and an increased risk of postmenopausal breast cancer.

To date, studies have evaluated individual components of the metabolic syndrome and breast cancer, however, this is the first time researchers have assessed whether women who met the criteria of having the metabolic syndrome were at greater risk for postmenopausal breast cancer.

For free information about breast cancer, contact the medical malpractice attorneys of Pittsburgh, Pennsylvania at Berger & Lagnese.



5/4/2009
Joshua L. Berger
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Breast Cancer Patients have Vitamin D Deficiency

It is known that Vitamin D deficiency is associated with increased risk of breast cancer and decreased survival.  A new study quantified the prevalence of Vitamin D deficiency in women with breast cancer.  This study, from physicians at Columbia University, found that 74% of women with breast cancer were Vitamin D deficient.  They prescribed vitamin D and calcium carbonate for one year but only 15% were able to achieve normal vitamin D levels.  Optimal dosing for bone health is still unknown  This study was supported by the National Cancer Institute and published in the Journal of Clinical Oncology.

More free information about breast cancer is available from the breast cancer malpractice attorneys of Pennsylvania.



4/6/2009
Lisa Wisilosky
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Radiation after Mastectomy for Breast Cancer is Being Underutilized

In a study published in Cancer, nearly 20% of women with breast cancer who would benefit from radiation after mastectomy, also known as post-mastectomy radiation treatment (PMRT), are not receiving the treatment.

In 2001, the American Society of Clinical Oncology (ASCO) released clinical practice guidelines for PMRT.

The researchers surveyed the women and assessed the rates of explanation, recommendation, and utilization of PMRT based on the ASCO guidelines.  The study found that radiation delivered after a mastectomy has been shown to reduce the risk of cancer returning in the chest wall and improve survival in high-risk patients.

The researchers concluded that approximately one-fifth of women who could benefit from PMRT did not receive treatment.

For free information about breast cancer, contact the Pennsylvania breast cancer malpractice attorneys.  



3/30/2009
David M. Paul
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New Marker Identified for Breast Cancer Metastasis

As reported in the March 24 online edition of the journal Clinical Cancer Research, researchers at NewYork-Presbyterian Hospital/Weill Cornell Medical Center have identified a new marker for breast cancer metastasis called TMEM, for Tumor Microenvironment of Metastasis.  According to the new research, density of TMEM is associated with the development of distant organ metastasis via the bloodstream -- the most common cause of death from breast cancer.  This research may lead to the first test to predict the likelihood of breast cancer metastasis via the bloodstream, and ultimately to changes the way breast cancer is treated.

An estimated 40 percent of all breast cancer patients relapse and develop metastatic disease.  Traditionally, the likelihood of breast cancer metastasis is estimated based on tumor size, tumor differentiation -- how similar or dissimilar the tumor is compared to normal breast tissue -- and whether the cancer has spread to the lymph nodes.  TMEM density may prove to be more determinative of the likelihood of breast cancer metastatis than these traditional measures.

If your breast cancer was missed or misdiagnosed, see the breast cancer malpractice lawyers of Pennsylvania. Berger & Lagnese is a law firm that specializes in breast cancer medical malpractice cases. We work on cases in Pittsburgh and all over Western Pennsylvania, including Greensburg, Washington, Uniontown, Beaver, and Erie.


3/26/2009
David M. Paul
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Black Women Face Three Times Greater Risk of Aggressive Breast Cancer

A new study published in the open access journal Breast Cancer Research has found that black women face three times the risk of developing an aggressive "triple negative tumor" breast cancer compared to women of other racial backgrounds.  Triple negative tumors are breast cancer tumors that lack expression of the estrogen receptor, the progesterone receptor, and the HER2 gene.

The United States has the highest rate of breast cancer in the world.  The overall incidence of breast cancer in the United States is lower in black women than in white women; however, according to the new study, when black women do get breast cancer, their cancer tends to be more advanced when diagnosed, has a higher risk or recurring, and a less favorable outcome.

If your breast cancer was missed or misdiagnosed, see the breast cancer malpractice lawyers of Pennsylvania. Berger & Lagnese is a law firm that specializes in breast cancer medical malpractice cases. We work on cases in Pittsburgh and all over Western Pennsylvania, including Greensburg, Washington, Uniontown, Beaver, and Erie.


 


2/19/2009
David M. Paul
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Bone Density Drug Tibolone Found to Increase Risk of Breast Cancer Recurrence

The February 2009 issue of The Lancet Oncology reports that a breast cancer patient´s risk of recurrence increases considerably with the use of Tibolone, a synthetic steroid used in preventing osteoporosis and treating menopausal symptoms.  As a result, breast cancer survivors and current breast cancer patients should not be givenTibolone.

In August, 2008, The New England Journal of Medicine reported that Tibolone increases the risk of stroke in older women.


2/12/2009
David M. Paul
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Bone Drug May Help Prevent Breast Cancer

A new study published in The New England Journal of Medicine has found that a drug of a class commonly used to combat bone loss may reduce by a third the chance that some breast cancers will spread or recur.

The new study involved 1,803 premenopausal women with breast tumors that were fueled by estrogen. As part of their treatment, all received drugs that shut down their ovaries, preventing them from making estrogen, along with drugs that stymie cancer cells from using estrogen to grow.  Half also got the bone drug zoledronic acid, or Zometa, as an intravenous infusion twice a year for three years. Those who took the drug had a 36 percent reduction in cancer recurrences and metastases, compared with women who did not get it.

If your breast cancer was missed or misdiagnosed, see the breast cancer malpractice lawyers of Pennsylvania. Berger & Lagnese is a law firm that specializes in breast cancer medical malpractice cases. We work on cases in Pittsburgh and all over Western Pennsylvania, including Greensburg, Washington, Uniontown, Beaver, and Erie.


2/11/2009
Joshua L. Berger
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Risk of Breast Cancer Decreases After Stopping Hormone Treatment

The Women's Health Initiative (WHI) studied the use of the hormones, estrogen and progestin.  In 2002 a report of that study was released.  In that trial one group received 0.625 mg of estrogen plus 2.5 mg of progestin daily.  A second group received placebo.  There were fewer breast cancer diagnoses in the group receiving estrogen plus progestin than in the placebo group in the initial 2 years of the study, but the number of diagnoses increased over the course of the 5.6-year intervention period. The elevated risk decreased rapidly after both groups stopped taking the study pills. In the observational study, the incidence of breast cancer was initially about two times as high in the group receiving menopausal hormones as in the placebo group, but this difference in incidence decreased rapidly in about 2 years, coinciding with year-to-year reductions in combined hormone use.

The conclusion is that the increased risk of breast cancer associated with the use of estrogen plus progestin declined markedly soon after discontinuation of the hormone therapy.

 

 



2/3/2009
Joshua L. Berger
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For Breast Biopsy 11-Gauge Needle Better than 14-Gauge Needle

According to a recent study performed at the Stanford University School of Medicine, stereotactic vacuum-assisted breast needle biopsy is more effective with an 11-gauge needle than the 14-gauge needle.  There is less chance of a false-negative diagnoses with the 11-gauge needle than with the 14-gauge needle.  The study appears in the February 2009 issue of the American Journal of Roentgenology.

If your breast cancer was missed or misdiagnosed, see the breast cancer malpractice lawyers of Pennsylvania. Berger & Lagnese is a law firm that specializes in breast cancer medical malpractice cases. We work on cases in Pittsburgh and all over Western Pennsylvania, including Greensburg, Washington, Uniontown, Beaver, and Erie.


1/21/2009
David M. Paul
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Radiation Lowers Relapse Risk In Noninvasive Breast Cancer

A new review confirms that the addition of radiation therapy to lumpectomy in the treatment of ductal carcinoma in situ (DCIS), a noninvasive early form of breast cancer, substantially decreases the risk of recurrence of either DCIS or invasive breast cancer in the affected breast.  In addition, there appear to be no long-term side effects from the radiation, such as damage to the heart or lungs.

The review appears in the latest issue of The Cochrane Library, a publication of The Cochrane Collaboration, an international organization that evaluates medical research.

If your breast cancer was missed or misdiagnosed, see the breast cancer malpractice lawyers of Pennsylvania. Berger & Lagnese is a law firm that specializes in breast cancer medical malpractice cases. We work on cases in Pittsburgh and all over Western Pennsylvania, including Greensburg, Washington, Uniontown, Beaver, and Erie.


1/19/2009
Joshua L. Berger
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Twice as Long to Read Digital Mammograms

Interpretation of digital screening mammograms takes twice as long as interpretation of film-screen mammograms, according to a report in the January issue of the American Journal of Roentgenology.

The differences ranged from 76 to 202 seconds longer.  The average interpretation time was 240 seconds (4 minutes) for digital screening mammograms and 127 seconds (2 minutes, 7 seconds) for film-screen screening mammograms.  At a high-volume hospital, this could add up to a significant difference.

There are advantages of digital mammography that offset the disadvantage of longer interpretation times.  It's easier to obtain the images. The images are also easier to store and transport. Finally, there have been three studies showing digital mammograms are more accurate than regular film mammography at finding breast cancer.

Taking longer to read all digital mammograms is not a problem; the problem comes from taking longer and still trying to read the same number of mammograms.



1/19/2009
Joshua L. Berger
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Men with Breast Cancer Have Distinct Findings on Mammogram

Men who develop breast cancer usually present with an irregular subareolar mass with speculated or indistinct margins on mammogram, according to a report in the December issue of the American Journal of Roentgenology.

It is necessary to be attentive to any palpable masses and to obtain mammogram early.

This study proves that punctuate calcifications on mammogram and circumscribed masses on ultrasound can be associated with cancer in men.  Radiologists should be aware of these findings to avoid the misdiagnosis of cancer in men as a benign lesion.



12/31/2008
Joshua L. Berger
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Possible Good News for Women with Breast Cancer Who Suffer from Lymphedema

The Washington Post reports that hospitals in about a dozen states are currently testing whether some simple steps, such as arm-strengthening exercises, could reduce the risk of one of breast cancer's troubling legacies:  The painful and sometimes severe arm swelling called lymphedema. Lymphedema has long been a known side effect of breast cancer surgery and radiation.  However, even though spotting and treating lymphedema early improves outcomes, many women with breast cancer who develop lymphedema are never diagnosed or treated.  According to a recent study published in November's Journal of Clinical Oncology, as many as 37% of breast cancer patients who develop lymphedema are neither diagnosed nor treated for the ailment.

Among the techniques to combat lymphedema that are currently being examined:  Wearing elastic sleeves to counter temporary swelling during things like airplane flight or heavy lifting; and doing special exercises with light weights designed to help keep open the lymph channels that allow fluid to drain through the body.

For information about breast cancer, see the breast cancer malpractice lawyers of Pennsylvania, headquartered in Pittsburgh, PA.

12/29/2008
David M. Paul
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Doctors Failing to Inform Women with Breast Cancer of Reconstructive Surgery Options

The New York Times recently examined reconstructive breast surgery options provided to cancer patients undergoing mastectomies.   According to the Times, despite recent advances in reconstructive breast surgery procedures, many plastic surgeons are failing to inform women about the extent of their reconstruction surgery options.  The reason for this, according to the Times, is that some plastic surgeons are not trained to perform the latest operations, and others lack incentives to promote surgeries that are less profitable for physicians and hospitals.

Approximately 66,000 women in the U.S. have a mastectomy each year and about 57,000 women have reconstructive breast surgery.  Implant surgery, which initially involves the least surgery and shortest recovery time, is the most popular breast reconstructive method in the U.S., but implants also can lead to future problems and additional surgeries.  Newer procedures, called flaps, generally involve transplanting a wedge of fat tissue and blood vessels from the abdomen or buttocks and reforming them into new breasts.  The most common flap procedure, called a TRAM flap, uses abdominal fat and muscle containing blood vessels to rebuild the breast.  A newer technique, called the DIEP free flap, uses fat only and does not use abdominal muscle.

For information about breast cancer, see the breast cancer malpractice lawyers of Pennsylvania, headquartered in Pittsburgh, PA.

12/22/2008
David M. Paul
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Computer-Aided Mammography Finds More Cancer

According to a recent systematic review of research conducted to date, computer programs that interpret mammograms ("computer-aided detection" or "CAD") are helpful in assisting radiologists to identify areas in the breast that are suspicious for breast cancer.  Typically, a radiologist examines a woman's screening mammogram to check for signs of cancer.  When using CAD with mammography, the radiologist still reads the mammogram, but a computer program also evaluates the mammogram and marks suspicious areas for the radiologist to review further.

This new review indicates that CAD mammography identifies an estimated 50 additional cancer diagnoses for every 100,000 women than are identified without the assistance of CAD.

For more information about breast cancer, see the breast cancer attorneys of Pennsylvania.

12/22/2008
David M. Paul
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Women at High Risk of Breast Cancer Benefit from Alternating MRI and Mammography

According to research conducted by doctors at the University of Texas M. D. Anderson Cancer Center, magnetic resonance imaging (MRI) alternated with mammography at six-month intervals can detect breast cancers not identified by mammography alone.

MRI is known to be more sensitive in detecting breast cancers than mammography, with a 71 - 100 percent accuracy compared to a 16 - 40 percent accuracy for mammography.  As a result, annual breast cancer screening for high-risk women now typically includes MRI along with mammography and a clinical breast exam.

For more information about breast cancer, see the breast cancer attorneys of Pennsylvania

11/24/2008
Joshua L. Berger
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Vitamin D Reduces Risk of Breast Cancer

Vitamin D from dietary intake and sunlight exposure early in life is associated with lower risks for hormone receptor-positive breast cancers and hormone receptor-negative tumors, according to findings published in the October 15th issue of the American Journal of Epidemiology.

Intake of vitamin D during adolescence and early adulthood was most consistently associated with a significantly reduced risk of ER+/PR+ tumors.

An association was found between ever having taken cod liver oil at ages 10 to 19 years and a significantly reduced risk of breast cancer.

Similar to the dietary findings, the team found that greater sun exposure earlier in life was more consistently associated with a reduced risk of breast cancer.

Free information about breast cancer is available from the breast cancer malpractice attorneys of Pennsylvania.



11/20/2008
David M. Paul
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Breast Cancer Drug Avastin Increases Risk of Blood Clots

According to a new study published in the Journal of the American Medical Association, the breast cancer drug Avastin increases a patient's risk of developing blood clots in the veins, a condition known as venous thromboembolism (VTE).

According to the new study, which analyzed 15 earlier studies, 7.3% of breast cancer patients taking Avastin developed VTE. Overall, patients who took Avastin had a 33% increased risk of developing VTE than did patients who did not take the drug, and the risk was higher regardless of whether patients were taking a low or high dose.  The study's author Shenhong Wu of Stony Brook University has stated that the magnitude of the drug's risk were not known previously because earlier studies were too small to identify clear trends.  The study's authors advise that Avastin should receive a "black box" warning from FDA, the agency's strongest warning.

For information about breast cancer, see the breast cancer malpractice lawyers of Pennsylvania, headquartered in Pittsburgh, PA.


11/17/2008
David M. Paul
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New Vaccine for HER2-Positive Breast Cancer has Promising Results in Mice

HER2 is a receptor that sits on the surface of cells in normal breast tissue.  The job of this receptor is to promote cell growth.  However, too many HER2 receptors can lead to uncontrolled tissue growth and the development of what is called HER2-positive breast cancer.  Up to 30% of all breast cancer is HER2-positive.

Currently, there are a number of drugs in use that bind to and disable the out-of-control HER2 receptors in HER2-positive breast cancer patients.  However, many such patients develop a resistance to such drugs.  Once resistance is developed, these drugs are no longer effective at disabling the out-of-control HER2 receptors.   

In a study to be published in the September 15, 2008 edition of the journal Cancer Research, researchers at the Karmanos Cancer Institute in Detroit have created a vaccine that is effective at disabling HER-2 receptors, even those that have become resistant to the anti-HER2 drugs, when tested in mice.  The researchers hope this advance will lead to a vaccine for women whose HER2-positive breast cancers have become resistant to anti-HER2 drugs.


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