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Does treatment of acne with drugs increase risk of suicide attempts?

Research studies show that suffering severe acne may increase risk for suicide, and treating the acne with Isotretinoin might increase that risk.  Isotretinoin is also sold under various brand names including Accutane, Claravis, and Sotret.

Although Isotretinoin has been anecdotally linked to suicide, observational studies have had inconsistent results. In other studies, severe acne itself increased risks for distress and suicide.
Having severe acne may be a risk factor for suicide, given that attempt rates increased before isotretinoin was initiated. The further increase in rates after isotretinoin initiation indicates that the medication could heighten the risk. The results argue for close monitoring of all isotretinoin-treated patients for suicidal behavior for up to a year after treatment stops.